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Updated: Jul 16, 2026

Systemic Bacterial Infection and Immune Defense Phenotypes in Drosophila Melanogaster
10:12

Systemic Bacterial Infection and Immune Defense Phenotypes in Drosophila Melanogaster

Published on: May 13, 2015

Drosophila eiger mutants are sensitive to extracellular pathogens.

David S Schneider1, Janelle S Ayres, Stephanie M Brandt

  • 1Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America. dschneider@stanford.edu

Plos Pathogens
|March 27, 2007
PubMed
Summary

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Eiger, a tumor necrosis factor homolog in Drosophila, aids in fighting extracellular infections but can also cause pathology. Eiger mutants show impaired immunity against extracellular microbes but not intracellular ones.

Area of Science:

  • Immunology
  • Microbiology
  • Genetics

Background:

  • Eiger, a Drosophila tumor necrosis factor homolog, was previously shown to contribute to pathology during Salmonella typhimurium infection.
  • The dual role of Eiger in infection pathology and immunity remained unclear.

Purpose of the Study:

  • To investigate the specific roles of Eiger in combating different types of microbial infections in Drosophila.
  • To determine whether Eiger's function is solely detrimental or if it also confers protective immunity.

Main Methods:

  • Challenging wild-type and Eiger mutant Drosophila flies with a diverse panel of facultative intracellular and extracellular pathogens.
  • Assessing the differential immune responses and survival rates of flies against various microbial species.

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Last Updated: Jul 16, 2026

Systemic Bacterial Infection and Immune Defense Phenotypes in Drosophila Melanogaster
10:12

Systemic Bacterial Infection and Immune Defense Phenotypes in Drosophila Melanogaster

Published on: May 13, 2015

Assessing the Cellular Immune Response of the Fruit Fly, Drosophila melanogaster, Using an In Vivo Phagocytosis Assay
05:50

Assessing the Cellular Immune Response of the Fruit Fly, Drosophila melanogaster, Using an In Vivo Phagocytosis Assay

Published on: April 10, 2019

Drosophila melanogaster Larva Injection Protocol
03:16

Drosophila melanogaster Larva Injection Protocol

Published on: October 19, 2021

Main Results:

  • Eiger mutant flies exhibited compromised immunity against extracellular pathogens, indicating a protective role for Eiger in these infections.
  • Conversely, Eiger mutants showed no significant change or even reduced sensitivity to facultative intracellular pathogens.
  • These findings suggest Eiger activates cellular immune responses crucial for clearing extracellular microbes.

Conclusions:

  • Eiger plays a dichotomous role in host defense, promoting immunity against extracellular pathogens while potentially contributing to pathology.
  • The fly's immune system, modulated by Eiger, differentially combats extracellular versus intracellular microbes.