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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

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Epidermolytic hyperkeratosis within infundibular cysts.

Chynna L Steele1, Christopher R Shea, Vesna Petronic-Rosic

  • 1University of Chicago, Section of Dermatology, Chicago, IL 60637, USA.

Journal of Cutaneous Pathology
|March 27, 2007
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Summary

Epidermolytic hyperkeratosis (EH), a skin condition, was found within follicular cysts in two rare cases. This histopathologic pattern is typically seen in bullous congenital ichthyosiform erythroderma.

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Area of Science:

  • Dermatopathology
  • Genodermatoses
  • Histopathology

Background:

  • Epidermolytic hyperkeratosis (EH) is a recognized histopathologic pattern.
  • It is primarily associated with bullous congenital ichthyosiform erythroderma, an autosomal dominant genodermatosis.
  • EH can also occur in conditions involving mosaicism.

Observation:

  • EH has been incidentally found in various skin lesions, including nevi, scars, and carcinomas.
  • This study reports two cases of EH within infundibular type follicular cysts.
  • This finding is exceptionally rare, with only one prior report in 1978.

Findings:

  • The presence of epidermolytic hyperkeratosis within infundibular follicular cysts is documented.
  • This highlights an unusual localization for this specific histopathologic pattern.
  • The cases expand the known spectrum of conditions associated with EH.

Implications:

  • This finding may broaden the differential diagnosis for EH in follicular cysts.
  • Further research could explore the mechanisms leading to EH in this specific context.
  • Understanding these rare occurrences contributes to the comprehensive knowledge of genodermatoses and skin pathology.