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Updated: Jan 20, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
Urethral metastasis from a colon carcinoma
Ying-Hsu Chang1, Cheng-Keng Chuang, Kwai-Fong Ng
1Department of Surgery, Division of Uro-oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Abstract:
Urethral metastatic adenocarcinoma is rare. Only 9 such cases have been reported. We report a case of urethral metastasis from an ascending colonic adenocarcinoma. A 62-year-old man was diagnosed with Stage T4N0M0 ascending colon cancer. In September 2001, he underwent right hemicolectomy. In April 2004, he developed intermittent gross hematuria. Urethroscopy showed an exophytic tumor in the urethra, and biopsy revealed adenocarcinoma. Partial penectomy was performed. The pathologic examination showed moderately differentiated adenocarcinoma of the urethra consistent with the colonic primary. We describe the pathologic findings and immunohistochemical features of this case and briefly review the published reports.
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