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Related Experiment Videos

Cerebral blood perfusion changes in multiple sclerosis.

Jens Wuerfel1, Friedemann Paul, Frauke Zipp

  • 1Institute of Neuroimmunology, Charité Universitätsmedizin Berlin, Germany.

Journal of the Neurological Sciences
|March 27, 2007
PubMed
Summary

New magnetic resonance imaging techniques allow for better understanding of cerebral blood flow changes in multiple sclerosis. This review covers dynamic susceptibility contrast imaging and its application in studying inflammation-related perfusion alterations in patients.

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Area of Science:

  • Neuroscience
  • Radiology
  • Immunology

Background:

  • Immune cell aggregation near vasculature is characteristic of multiple sclerosis.
  • Inflammation is known to affect microcirculation.
  • Previous studies on cerebral blood perfusion in multiple sclerosis yielded inconsistent results due to technical challenges.

Purpose of the Study:

  • To review the technical principles and applications of dynamic susceptibility contrast (DSC) MRI for assessing cerebral hemodynamics.
  • To discuss potential pitfalls and quantification methods for cerebral blood volume and flow using DSC MRI.
  • To outline recent findings on perfusion changes associated with inflammation in multiple sclerosis.

Main Methods:

  • Utilizing fast magnetic resonance imaging techniques.

Related Experiment Videos

  • Employing dynamic susceptibility contrast (DSC) imaging.
  • Tracking dynamic changes of paramagnetic contrast agents to assess cerebral hemodynamics.

    • Main Results:

    • Advanced MRI techniques enable detailed imaging of cerebral hemodynamics.
    • DSC MRI offers potential for absolute quantification of cerebral blood volume and flow.
    • Inflammation-associated perfusion changes are linked to multiple sclerosis pathology.

    Conclusions:

    • Dynamic susceptibility contrast MRI is a valuable tool for evaluating cerebral hemodynamics in multiple sclerosis.
    • Understanding perfusion changes is crucial for pathological considerations in multiple sclerosis.
    • Further research can refine DSC MRI quantification for clinical settings.