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Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

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Soft tissue elastometer.

V Egorov¹, S Tsyuryupa, S Kanilo

¹Artann Laboratories, Trenton, NJ, USA.

Medical Engineering & Physics

|March 27, 2007

Summary

A new Tissue Elastometer (TE) accurately measures soft tissue elasticity (Young

Area of Science:

Biomedical Engineering
Materials Science
Mechanical Engineering

Background:

Accurate measurement of soft tissue elasticity is crucial for diagnosing and treating various medical conditions.
Existing methods for tissue elasticity assessment often lack precision or are difficult to implement in clinical settings.

Purpose of the Study:

To develop and validate a novel device, the Tissue Elastometer (TE), for precise measurement of soft tissue Young's modulus.
To assess the accuracy and repeatability of the TE using calibrated silicone phantoms and excised biological tissues.

Main Methods:

Developed the Tissue Elastometer (TE) with a linearly actuated indenter and an electronic balance.
Utilized a semi-infinite media deformation model for calculating Young's modulus from force-displacement data.

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Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

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Calibrated the TE using silicone mixtures with known Young's moduli (10-400 kPa).

Tested excised tissue samples including poultry breast, bovine liver, kidneys, hind shanks, and porcine tissues.

Main Results:

The TE demonstrated high accuracy (1-10%) for silicone samples within the calibrated Young's modulus range.
Repeatability of elasticity measurements on excised tissues was consistently achieved (8-14%).
The device effectively captured elasticity variations across different tissue types.

Conclusions:

The Tissue Elastometer (TE) provides a reliable and accurate method for evaluating soft tissue elasticity.
The TE is suitable for application in both laboratory research and clinical environments for tissue characterization.
This device has the potential to improve diagnostic capabilities and treatment planning related to tissue mechanical properties.