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Postoperative coagulopathy in a pediatric patient after exposure to bovine topical thrombin

Sheri S Crow1, Vita V Sullivan, Agnes E Aysola

  • 1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

The Annals of Thoracic Surgery
|March 27, 2007
PubMed

Insights

A child with congenital heart disease developed severe bleeding after surgery due to a rare factor V inhibitor. This highlights the importance of considering acquired inhibitors in postoperative coagulopathy.

Area of Science:

  • Cardiology
  • Hematology
  • Pediatric Surgery

Background:

  • Congenital heart disease (CHD) presents complex surgical challenges.
  • Acquired factor inhibitors are rare but critical complications.

Observation:

  • A pediatric patient with CHD developed severe, unexplained coagulopathy post-surgery.
  • The coagulopathy was linked to repeated exposure to bovine topical thrombin during the procedure.

Findings:

  • The patient developed a specific acquired factor V inhibitor.
  • This inhibitor was directly associated with bovine thrombin exposure, leading to severe bleeding complications.

Implications:

  • Pediatric providers must consider acquired factor inhibitors in postoperative coagulopathy, especially after exposure to bovine thrombin.
  • Early recognition and management of these inhibitors are crucial for patient outcomes.
  • Reviewing treatment options for acquired factor inhibitors is essential for managing such rare cases.

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