Related Experiment Video
Updated: Jul 16, 2026

11:19
Isolation of Human Ventricular Cardiomyocytes from Vibratome-Cut Myocardial Slices
Published on: May 10, 2020
Isolated noncompaction of the myocardium
Dinaldo Cavalcanti de Oliveira1, Marcelo Menezes Malta, Jairo Alves Pinheiro
1Hospital do Coração, São Paulo, SP, Brazil. doliveira@hcor.com.br
Arquivos Brasileiros De Cardiologia
|March 27, 2007
Summary
This study details a rare congenital heart defect, noncompaction of the myocardium (NCM). Early diagnosis through echocardiography is crucial for managing this condition.
Area of Science:
- Cardiology
- Congenital Heart Disease
Background:
- Noncompaction of the myocardium (NCM) is a rare congenital heart defect.
- Few cases have been published since its initial description 15 years ago.
Observation:
- A 37-year-old female presented with palpitations, extrasystoles, and ventricular bigeminy on ECG.
- Three-dimensional Doppler echocardiography showed prominent trabeculations and deep intertrabecular recesses with blood flow.
Findings:
- Cardiac MRI confirmed echocardiographic findings of isolated NCM.
- Clinical presentation and laboratory results supported the diagnosis.
Implications:
- Understanding echocardiographic findings aids in early diagnosis of NCM.
- Prompt diagnosis facilitates more adequate patient treatment and management.
Related Concept Videos
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy IV: Restrictive Cardiomyopathy
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Structure of Cardiac Muscles
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Layers of the Heart Wall
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...

