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Updated: Jul 16, 2026

Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity
Published on: February 17, 2017
Nonspecific electrostatic binding characteristics of the heparin-antithrombin interaction
Emek Seyrek1, Paul L Dubin, Jens Henriksen
1Department of Chemistry, Indiana University Purdue University Indianapolis, 402 N. Blackford St. Indianapolis, IN 46202, USA.
Abstract:
We evaluated the role of nonspecific electrostatic binding in the interaction of antithrombin (AT) with heparin (Hp), a paradigmatic protein-glycosaminoglycan (GAG) system. To do so, we obtained the ionic-strength dependence of the binding constant, since a common feature in protein-polyelectrolyte systems is a maximum in affinity in the ionic strength range 10 mM
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