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Updated: Jul 16, 2026
06:59
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Single-dose chloral hydrate for benign convulsions with mild gastroenteritis
Hideo Enoki1, Takuya Yokota, Rika Nagasaki
1Department of Child Neurology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan. enoki@sis.seirei.or.jp
Epilepsia
|March 28, 2007
Summary
Single-dose chloral hydrate (CH) effectively treated clustering seizures in children with gastroenteritis, with 86% efficacy. A dose of at least 40 mg/kg is recommended for successful treatment.
Area of Science:
- Pediatric Neurology
- Clinical Pharmacology
Background:
- Benign convulsions with mild gastroenteritis can present with clustering seizures.
- Effective and safe treatment options for these seizures are crucial in pediatric care.
Purpose of the Study:
- To evaluate the efficacy of a single-dose treatment with chloral hydrate (CH) for managing clustering seizures in children experiencing benign convulsions with mild gastroenteritis.
Main Methods:
- Retrospective analysis of treatment data from 33 pediatric patients (7-39 months old).
- Investigation of seizure time-series records and drug administration processes.
Main Results:
- Single-dose chloral hydrate (CH) achieved 86% efficacy (19/22 patients).
- Diazepam showed a lower efficacy of 13% (2/16 patients).
- Effective CH doses ranged from 41.7 to 62.5 mg/kg (mean 50.2 mg/kg).
Conclusions:
- Single-dose CH therapy demonstrates a significant advantage for treating clustering seizures in this population.
- A recommended minimum effective dose of chloral hydrate is 40 mg/kg.
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