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Resolution of pityriasis rubra pilaris-induced cicatricial ectropion with systemic low-dose methotrexate
Vikram D Durairaj1, Michael B Horsley
1Division of Oculoplastic and Orbital Surgery, Department of Ophthalmology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA. vikram.durairaj@uchsc.edu <vikram.durairaj@uchsc.edu>
Purpose:
To report a case of pityriasis rubra pilaris (PRP)-induced bilateral lower eyelid cicatricial ectropion that resolved with systemic low-dose methotrexate.
Design:
Observational case report.
Methods:
A retrospective case review of a patient with cicatricial ectropion caused by PRP.
Results:
A 82-year-old female presented with bilateral lower eyelid cicatricial ectropion secondary to PRP. The patient did not systemically respond to conventional oral retinoid therapy. She was treated with low-dose methotrexate and experienced dramatic resolution of her signs and symptoms, including complete resolution of her bilateral cicatricial ectropion.
Conclusion:
Systemic treatment of PRP with low-dose methotrexate may result in successful treatment of cicatricial ectropion without surgery.
