Related Experiment Video
Updated: Jul 16, 2026

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation
Published on: June 14, 2024
Gene function in mouse embryogenesis: get set for gastrulation
Patrick P L Tam1, David A F Loebel
1Embryology Unit, Children's Medical Research Institute and Faculty of Medicine, University of Sydney, Westmead, NSW 2145, Australia. ptam@cmri.usyd.edu.au
Abstract:
During early mouse embryogenesis, temporal and spatial regulation of gene expression and cell signalling influences lineage specification, embryonic polarity, the patterning of tissue progenitors and the morphogenetic movement of cells and tissues. Uniquely in mammals, the extraembryonic tissues are the source of signals for lineage specification and tissue patterning. Here we discuss recent discoveries about the lead up to gastrulation, including early manifestations of asymmetry, coordination of cell and tissue movements and the interactions of transcription factors and signalling activity for lineage allocation and germ-layer specification.
More Related Videos
Related Concept Videos
Gastrulation
Determination
Cleavage and Blastulation
Neurulation

