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Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

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Related Experiment Video

Updated: Jul 16, 2026

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation
09:14

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation

Published on: June 14, 2024

Gene function in mouse embryogenesis: get set for gastrulation.

Patrick P L Tam1, David A F Loebel

  • 1Embryology Unit, Children's Medical Research Institute and Faculty of Medicine, University of Sydney, Westmead, NSW 2145, Australia. ptam@cmri.usyd.edu.au

Nature Reviews. Genetics
|March 28, 2007
PubMed
Summary

Early mouse embryo development relies on precise gene expression and cell signaling for tissue formation. Mammalian extraembryonic tissues uniquely guide lineage specification and patterning before gastrulation.

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Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

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Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
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Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Biology

Background:

  • Early embryogenesis involves complex temporal and spatial regulation of gene expression and cell signaling.
  • Mammalian extraembryonic tissues play a unique role in providing signals for lineage specification and tissue patterning.
  • Understanding these early events is crucial for comprehending embryonic development.

Purpose of the Study:

  • To discuss recent discoveries concerning the period leading up to gastrulation in mouse embryos.
  • To highlight the early manifestations of asymmetry and the coordination of cell and tissue movements.
  • To explore the interactions of transcription factors and signaling pathways in lineage allocation and germ-layer specification.

Main Methods:

  • Review of recent scientific literature and discoveries.
  • Analysis of gene expression patterns and cell signaling pathways.
  • Investigation of early embryonic asymmetry and morphogenetic movements.

Main Results:

  • Early asymmetry manifests through coordinated cell and tissue movements.
  • Interactions between transcription factors and signaling activity are key for lineage allocation.
  • Extraembryonic tissues are critical signaling centers for germ-layer specification.

Conclusions:

  • Precise temporal and spatial regulation is essential for mouse embryogenesis.
  • Mammalian extraembryonic tissues are indispensable for guiding early developmental processes.
  • Further research into these early signaling interactions will illuminate fundamental developmental mechanisms.