Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited.

Area of Science:

• Developmental Biology
• Stem Cell Research
• Biomedical Ethics

Background:

• Human stem cell-based embryo models (SCBEMs) offer insights into human embryogenesis, reproductive technologies, and disease origins.
• SCBEMs present unique ethical considerations compared to other stem cell models like organoids.
• Existing 2021 ISSCR guidelines categorize SCBEM research oversight based on embryonic and extraembryonic lineage involvement.

Purpose of the Study:

• To re-examine and update existing guidelines for human stem cell-based embryo models (SCBEMs) in light of recent scientific advancements.
• To provide clearer recommendations for the ethical and scientific oversight of SCBEM research.
• To ensure continued public confidence in stem cell research involving embryo models.

Main Methods:

• A working group was convened by the International Society for Stem Cell Research (ISSCR) executive.
• The group conducted a thorough re-examination of the 2021 ISSCR guidelines.
• New recommendations were developed based on recent progress in creating complex SCBEMs.

Main Results:

• Research involving organized 3D human SCBEMs requires appropriate review.
• All human SCBEM research must possess a clear scientific rationale.
• Human SCBEM research should be conducted within limited, defined timelines.

Conclusions:

• The proposed modifications aim to bring clarity to the rapidly advancing field of SCBEMs.
• These updated guidelines will assist researchers, oversight committees, and stakeholders in navigating SCBEM research.
• Adherence to revised guidelines is crucial for maintaining scientific integrity and public trust.