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Distribution of rotavirus genotypes in Europe, 2004-2005: the REVEAL Study

Pierre Van Damme1, Carlo Giaquinto, Melanie Maxwell

  • 1Faculty of Medicine, Centre for the Evaluation of Vaccination, World Health Organization Collaborating Centre for the Control and Prevention of Viral Hepatitis, University of Antwerp, Antwerp, BE-2610, Belgium. pierre.vandamme@ua.ac.be

The Journal of Infectious Diseases
|March 28, 2007
PubMed

Insights

Rotavirus gastroenteritis (RVGE) is a major childhood illness. The study identified common rotavirus genotypes (G1-G4, G9) across Europe, highlighting geographic and seasonal variations crucial for vaccine development.

Area of Science:

  • Virology
  • Pediatrics
  • Epidemiology

Background:

  • Rotavirus gastroenteritis (RVGE) presents a substantial health challenge in children.
  • Understanding circulating rotavirus genotypes is essential for effective immunization strategies.

Purpose of the Study:

  • To identify prevalent rotavirus genotypes causing gastroenteritis in children across Europe.
  • To analyze the geographic and seasonal distribution of these genotypes.

Main Methods:

  • A prospective, multicenter observational study was conducted in children under 5 years old during the 2004-2005 RVGE season.
  • Rotavirus was detected using ELISA, and genotypes were determined by RT-PCR on stool samples.

Main Results:

  • Of 2712 children with gastroenteritis, 40.6% tested positive for rotavirus.
  • Genotypes G1-G4 and G9 were most prevalent, with distinct geographic distributions (e.g., G1 in UK, G9 in Italy, G4 in Germany).
  • G4 and G9 genotypes were found in all study regions, and seasonal variations in rotavirus strains were observed.

Conclusions:

  • Rotavirus genotypes G1-G4 and G9 are responsible for most RVGE cases in the studied European regions.
  • Significant geographic and seasonal variations in rotavirus strain distribution exist.
  • Rotavirus vaccines should target these major genotypes to reduce the disease burden effectively.
Abstract

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