Structure--antiadenoviral activity of nitrogen containing macroheterocycles and their analogues
N S Dyachenko1, L N Nosach, O Y Povnitsa
1Institute of Microbiology and Virology, National Academy Sciences of Ukraine, 154 Zabolotny St., Kyiv, MSP D03680, Ukraine.
Abstract:
The search for the inhibitors of adenoviruses has been performed among the substances of new class NCM (nitrogen containing macroheterocycles) and their analogues that have high potential of pharmacological properties. We have found a number of NCM and their derivatives that inhibit the reproduction of adenoviruses to various degrees. For the prediction of NCM structure with antiadenoviral activity we have performed the computer modeling using QSAR approach on the basis of simplex representation of molecular structure (SiRMS).
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