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Sequence analysis of the new allele HLA-A*020112

P A Horn1, M Hallensleben, B Eiz-Vesper

  • 1Institute for Transfusion Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Tissue Antigens
|March 29, 2007
PubMed

Abstract:

The novel allele HLA-A*020112 differs from HLA-A*020101 by a synonymous nucleotide exchange at position 53 in exon 2 (G-->A).

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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