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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Updated: Jul 16, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Inflammatory bowel disease.

L Jodell McLemore

    Radiologic Technology
    |March 29, 2007
    PubMed
    Summary

    Inflammatory bowel disease (IBD) involves gastrointestinal inflammation and symptoms like diarrhea and pain. Its causes are complex, involving genetics, immunity, environment, and antibiotics, diagnosed via endoscopic and lab tests.

    Area of Science:

    • Gastroenterology
    • Immunology
    • Genetics

    Background:

    • Inflammatory bowel disease (IBD) is characterized by gastrointestinal inflammation.
    • Symptoms include fever, abdominal pain, and diarrhea, which can be severe and bloody.

    Purpose of the Study:

    • To summarize the current understanding of inflammatory bowel disease.
    • To outline diagnostic and monitoring methods for IBD.

    Main Methods:

    • Review of current research on IBD causes and diagnosis.
    • Description of diagnostic tools such as endoscopic exams, radiologic techniques, and histologic laboratory tests.

    Main Results:

    • The exact causes of IBD remain unclear.
    • Current research points to a multifactorial etiology involving genetic predisposition, immune system dysregulation, environmental factors, and antibiotic use.

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    Investigating Intestinal Inflammation in DSS-induced Model of IBD
    08:43

    Investigating Intestinal Inflammation in DSS-induced Model of IBD

    Published on: February 1, 2012

    A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
    05:08

    A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

    Published on: March 1, 2022

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    Last Updated: Jul 16, 2026

    Chronic Salmonella Infection Induced Intestinal Fibrosis
    08:40

    Chronic Salmonella Infection Induced Intestinal Fibrosis

    Published on: September 22, 2019

    Investigating Intestinal Inflammation in DSS-induced Model of IBD
    08:43

    Investigating Intestinal Inflammation in DSS-induced Model of IBD

    Published on: February 1, 2012

    A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
    05:08

    A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

    Published on: March 1, 2022

    Conclusions:

    • IBD is a complex condition with multifactorial origins.
    • A combination of endoscopic, radiologic, and histologic methods aids in the diagnosis, treatment, and monitoring of IBD.