Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mesotherapy for local fat reduction.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2013

Same author

A novel cobiotic containing a prebiotic and an antioxidant augments the glucose control and gastrointestinal tolerability of metformin: a case report.

Beneficial microbes·2013

Same author

Abdominal adiposity depots are correlates of adverse cardiometabolic risk factors in Caucasian and African-American adults.

Nutrition & diabetes·2012

Same author

Enterostatin inhibition of angiogenesis: possible role of pAMPK and vascular endothelial growth factor A (VEGF-A).

International journal of obesity (2005)·2008

Same author

A rare mutation in AgRP, +79G>A, affects promoter activity.

European journal of clinical nutrition·2006

Same author

Using intranasal lidocaine to reduce food intake.

International journal of obesity (2005)·2006

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment

Published on: November 22, 2024

Topical fat reduction from the waist.

M K Caruso¹, S Pekarovic, W J Raum

¹Louisiana State University Division of Human Ecology, Baton Rouge, LA, USA.

Diabetes, Obesity & Metabolism

|March 30, 2007

Summary

Aminophylline cream effectively reduced waist circumference in a 12-week study. This topical treatment offers a safe, localized fat reduction method for the waist, with significant results observed in both men and women.

More Related Videos

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

Published on: July 28, 2018

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

Published on: September 27, 2021

Related Experiment Videos

Last Updated: Jul 16, 2026

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment

Published on: November 22, 2024

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

Published on: July 28, 2018

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

Published on: September 27, 2021

Area of Science:

Dermatology
Cosmetic Science
Metabolism

Background:

Topical aminophylline cream has shown efficacy in thigh fat reduction.
Limited research exists on its effectiveness in other body areas or in men.
The mechanism may involve lowering the local lipolytic threshold.

Purpose of the Study:

To investigate the efficacy of aminophylline cream for localized fat reduction on the waist.
To test the hypothesis that topical aminophylline cream reduces waist circumference compared to a control group.
To evaluate safety and effectiveness in a diverse population.

Main Methods:

A randomized controlled trial involving 50 men and women (BMI > 27 kg/m², high waist-to-hip ratio).
Participants applied 0.5% aminophylline cream to the waist twice daily or received no treatment.
Subjects followed a 1200 kcal diet and walking program for 12 weeks.

Main Results:

Significant reduction in waist circumference observed in the aminophylline group (11 cm) versus control (5 cm) (p < 0.001).
Both men and women experienced waist circumference reduction, with women showing greater loss.
No significant difference in BMI reduction between groups; waist-to-hip ratio declined. Aminophylline levels were undetectable, with no adverse events.

Conclusions:

Aminophylline cream is a safe and effective method for cosmetic local fat reduction from the waist.
The study supports its use for targeted circumference reduction.
Further research may explore optimal application and long-term effects.