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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Quantification of brain tissue alterations in Fabry disease using diffusion-tensor imaging.

Andreas Fellgiebel1, Juliane Albrecht, Paulo R Dellani

  • 1Department of Psychiatry, University Hospital of Mainz, Mainz, Germany. fellgiebel@psychiatrie.klinik.uni-mainz.de

Acta Paediatrica (Oslo, Norway : 1992)
|March 30, 2007
PubMed
Summary

Diffusion tensor imaging (DTI) reveals subtle central nervous system changes in Fabry disease earlier than conventional MRI. This advanced technique offers better monitoring for brain tissue alterations and treatment efficacy.

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Area of Science:

  • Neurology
  • Radiology
  • Genetics

Background:

  • Central nervous system (CNS) involvement is a significant complication of Fabry disease.
  • Conventional cranial magnetic resonance imaging (MRI) detects macroangiopathic changes like white matter lesions (WMLs) and vascular abnormalities.

Purpose of the Study:

  • To evaluate the sensitivity of diffusion tensor imaging (DTI) in detecting early structural brain changes in Fabry disease compared to conventional MRI.

Main Methods:

  • Utilized diffusion tensor imaging (DTI), a novel MRI technique measuring water diffusion characteristics.
  • Assessed brain tissue alterations, particularly in the periventricular white matter.

Main Results:

  • DTI identified marked brain tissue alterations in Fabry disease patients, predominantly in the periventricular white matter.
  • Significantly elevated brain tissue diffusivity was observed even in patients with minimal white matter lesions (WMLs).

Conclusions:

  • Diffusion tensor imaging (DTI) is more sensitive than conventional MRI for detecting CNS structural changes in Fabry disease.
  • DTI-derived parameters show potential as surrogate markers for monitoring disease progression and therapeutic response, including enzyme replacement therapy.