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Updated: Jul 16, 2026

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
Evaluation of bilayer disks as plant cell membrane models in partition studies
Elisabet Boija1, Anna Lundquist, Katarina Edwards
1Department of Biochemistry and Organic Chemistry, Biomedical Center, Uppsala University, SE-751 23 Uppsala, Sweden.
Abstract:
We have studied the partitioning of a set of phenolic compounds used as lignin precursor models into lipid bilayer disks and liposomes. The bilayer disks are open bilayer structures stabilized by polyethylene glycol-conjugated lipids. Our results indicate that disks generate more accurate partition data than do liposomes. Furthermore, we show that the partitioning into the membrane phase is reduced slightly if disks composed of 1,2-distearoyl-sn-glycero-3-phosphocholine and cholesterol are exchanged for disks with a lipid composition mimicking that of the root tissue of Zea mays L.
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