Extending the pathway analysis framework with a test for transcriptional variance implicates novel pathway modulation

Daniel M Kemp1, N R Nirmala, Joseph D Szustakowski

  • 1Diabetes and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

Summary

This study introduces a new statistical method for analyzing microarray data, identifying novel pathways in muscle differentiation by examining transcriptional variance. This approach enhances the detection of complex gene regulation patterns.

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