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Updated: Jul 16, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
Published on: November 29, 2013
Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term
Ping Jun Zhu1, David M Lovinger
1Lab. for Integrative Neuroscience, NIH/NIAAA, 5625 Fishers Lane, Rm. TS-28, Bethesda, MD 20892-9411, USA.
Abstract:
Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we show that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatergic synapses. These endocannabinoid-mediated plastic changes could contribute to information storage within the brain.
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