Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Same author

Motor cortex somatostatin interneurons adaptively shape the structure of action sequences.

Nature communications·2026

Same author

Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.

bioRxiv : the preprint server for biology·2026

Same author

SqueakPose Studio: An end-to-end platform for pose estimation and real-time edge-AI deployment.

bioRxiv : the preprint server for biology·2026

Same author

Neurotoxic effects of chronic ethanol on cholinergic interneurons in the dorsomedial striatum.

Neuropharmacology·2025

Same author

Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice.

bioRxiv : the preprint server for biology·2025

Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026

Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026

Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026

Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026

Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026

Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 4, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

External Globus Pallidus Arkypallidal Circuit Dynamics Gate Risk-Taking Behavior.

David L Haggerty^1,2, Beatriz D Sorigotto^3,4, Armando G Salinas⁵

¹Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

Biorxiv : the Preprint Server for Biology

|April 3, 2026

Summary

This summary is machine-generated.

The globus pallidus externa (GPe) regulates risk-taking behavior. Specific GPe NPAS1 neurons modulate decision-making by encoding risk, revealing a new neural circuit mechanism for adaptive behavior.

More Related Videos

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Published on: August 4, 2018

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Published on: June 22, 2017

Related Experiment Videos

Last Updated: Apr 4, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Published on: August 4, 2018

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Published on: June 22, 2017

Area of Science:

Neuroscience
Behavioral Biology
Computational Neuroscience

Background:

Exploration is crucial for adaptation but involves risks, necessitating neural systems for managing uncertainty and behavioral states.
The basal ganglia, particularly the globus pallidus externa (GPe), play a key role in integrating information for action selection and regulating behavior.

Purpose of the Study:

To investigate the role of arkypallidal NPAS1-expressing GPe (GPe NPAS1) neurons in regulating risk-taking behavior.
To identify the circuit mechanisms by which the GPe influences adaptive decision-making under uncertainty.

Main Methods:

Utilized chemogenetic manipulations to alter GPe NPAS1 neuron activity.
Employed in vivo calcium imaging to measure neural activity during behavioral tasks.
Examined the impact on risk-taking behavior sequences and decision-making.

Main Results:

GPe NPAS1 neuron activity was found to modulate risk-taking behavior sequences.
The activity of these neurons encodes information related to risk-taking.
Identified a specific neural circuit involving GPe NPAS1 neurons regulating adaptive decision-making.

Conclusions:

GPe NPAS1 neurons are critical regulators of risk-taking behavior.
These neurons provide a mechanism for the GPe to influence adaptive decision-making in uncertain environments.
Highlights the underappreciated role of the GPe in integrating information for behavioral flexibility.