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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Acute postoperative endophthalmitis caused by Staphylococcus lugdunensis
C Chiquet1, A Pechinot, C Creuzot-Garcher
1Department of Ophthalmology, CHU de Grenoble, Faculté de Médecine, Université Joseph Fourier, Grenoble, France. cchiquet@chu-grenoble.fr
Journal of Clinical Microbiology
|March 30, 2007
Summary
Staphylococcus lugdunensis rarely causes acute postoperative endophthalmitis after cataract surgery. This severe infection requires prompt, aggressive treatment, often including pars plana vitrectomy, to preserve vision.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Acute postoperative endophthalmitis is a severe intraocular infection following ocular surgery.
- Staphylococcus lugdunensis is an uncommon cause of post-cataract surgery endophthalmitis.
Observation:
- A multicenter study identified five cases of S. lugdunensis endophthalmitis post-cataract surgery.
- Patients presented with severe ocular inflammation, visual loss, and vitreous infiltration 7.6 days post-surgery.
- Standard antibiotic protocols were initiated, but four patients required pars plana vitrectomy due to infection severity.
Findings:
- Despite antibiotic sensitivity, three cases developed severe retinal detachment, complicating visual prognosis.
- Microbiological diagnosis involved conventional cultures, biochemical tests, and PCR with sequencing.
- S. lugdunensis presents a significant challenge in managing post-cataract surgery endophthalmitis.
Implications:
- Highlights the need for vigilance regarding S. lugdunensis as a potential pathogen in endophthalmitis.
- Suggests that aggressive surgical management may be necessary even with sensitive bacteria.
- Emphasizes the importance of advanced microbiological techniques for accurate diagnosis.
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