Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypertension and vascular dementia.

L A Petty1, J R Parker, J C Parker

  • 1Department of Pathology, University of Missouri-Kansas City 64108.

Annals of Clinical and Laboratory Science
|January 11, 1992
PubMed
Summary

Chronic hypertension can cause significant brain damage, including strokes and hemorrhages, even if vessel changes aren't always apparent postmortem. Further research is needed on intermittent hypertension's effects on the nervous system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case of Placenta Prævia.

Medical examiner (Philadelphia, Pa.)·2023
Same author

Chloro-Nitrous Oxyd.

The Dental register·2021
Same author

The Survival of the Unfit in Human Dentition.

The Dental register·2021
Same author

Estimating oil spill characteristics from oil heads in scattered monitoring wells.

Environmental monitoring and assessment·2013
Same author

Automated region of interest analysis of dynamic Ca²+ signals in image sequences.

American journal of physiology. Cell physiology·2012
Same author

On the Use of the Speculum in Uterine Diseases.

Provincial medical journal and retrospect of the medical sciences·2011

Area of Science:

  • Neurology
  • Pathology
  • Vascular Biology

Background:

  • Chronic hypertension is a major risk factor for cerebrovascular disease.
  • Postmortem studies often underestimate the extent of hypertensive brain damage.
  • Understanding the neuropathological consequences of hypertension is crucial for patient outcomes.

Observation:

  • Autopsies reveal that hypertension affects cerebral arteries, arterioles, and capillaries.
  • Hypertensive alterations include infarcts, hemorrhages, cerebral edema, atherosclerosis, fibrinoid necrosis, and micro-aneurysms.
  • Chronic hypertensive encephalopathy is linked to vascular dementia and specific white matter changes.

Findings:

  • Hypertensive vascular lesions can manifest as isolated or diffuse infarcts and hemorrhages.
  • Rapidly progressive hypertension may lead to widespread cerebral edema.
  • Chronic hypertensive encephalopathy is associated with subcortical arterial and arteriolar leukoencephalopathy, leukoaraiosis, and Binswanger's disease.

Implications:

  • Complete autopsy studies must correlate therapeutic compliance and diagnosis with long-term neurological effects.
  • Persistent, poorly controlled hypertension causes both acute and chronic brain damage.
  • The neurological impact of intermittent hypertension requires further investigation.

Related Experiment Videos