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Related Concept Videos

Alkynes to Aldehydes and Ketones: Acid-Catalyzed Hydration02:40

Alkynes to Aldehydes and Ketones: Acid-Catalyzed Hydration

Introduction
Analogous to alkenes, alkynes also undergo acid-catalyzed hydration. While the addition of water to an alkene gives an alcohol, hydration of alkynes produces different products such as aldehydes and ketones.
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration02:34

Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration

The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
Regioselectivity and Stereochemistry of Hydroboration02:36

Regioselectivity and Stereochemistry of Hydroboration

A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn stereochemistry.
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
High-Performance Liquid Chromatography: Introduction01:11

High-Performance Liquid Chromatography: Introduction

High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:
High-Performance Liquid Chromatography: Elution Process01:05

High-Performance Liquid Chromatography: Elution Process

In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...

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Updated: Jul 16, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
08:24

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Published on: November 11, 2008

From inconsistent results to high speed hydrosilylation.

Virginie Comte1, Cédric Balan, Pierre Le Gendre

  • 1Laboratoire de Synthèse et Electrosynthèse Organométalliques LSEO-UMR 5188, Faculté des Sciences Mirande, Dijon, France. virginie.comte@u-bourgogne.fr

Chemical Communications (Cambridge, England)
|March 30, 2007
PubMed
Summary

Dihydrogen gas accelerates rhodium-catalyzed hydrosilylation reactions. This study developed a high-speed hydrosilylation process utilizing in situ generated dihydrogen for enhanced reaction rates.

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Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
09:37

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

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Last Updated: Jul 16, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
08:24

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Published on: November 11, 2008

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
09:37

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

Area of Science:

  • Organometallic Chemistry
  • Catalysis
  • Organic Synthesis

Background:

  • Hydrosilylation is a key reaction in organic synthesis.
  • Rhodium catalysts are widely used for hydrosilylation.
  • Reaction rates can be limited by catalyst efficiency.

Purpose of the Study:

  • To investigate the effect of in situ generated dihydrogen on rhodium-catalyzed hydrosilylation.
  • To develop a high-speed hydrosilylation reaction protocol.

Main Methods:

  • Partial hydrolysis of silane in the presence of residual water to generate dihydrogen in situ.
  • Rhodium-catalyzed hydrosilylation of acetophenone under dihydrogen pressure.

Main Results:

  • In situ generated dihydrogen significantly enhances the rate of acetophenone hydrosilylation.
  • A high-speed hydrosilylation reaction was successfully developed.

Conclusions:

  • Dihydrogen is a key promoter for rhodium-catalyzed hydrosilylation.
  • This method offers a faster route for synthesizing silylated compounds.