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Updated: Jul 16, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
From inconsistent results to high speed hydrosilylation
Virginie Comte1, Cédric Balan, Pierre Le Gendre
1Laboratoire de Synthèse et Electrosynthèse Organométalliques LSEO-UMR 5188, Faculté des Sciences Mirande, Dijon, France. virginie.comte@u-bourgogne.fr
Abstract:
After noting that the presence of dihydrogen, generated in situ from the partial hydrolysis of a silane with residual water, significantly enhances the rate of the rhodium-catalysed hydrosilylation of acetophenone, we developed a high speed hydrosilylation reaction under dihydrogen pressure.
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