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Quantitation of Endothelial Cell Adhesiveness In Vitro

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Angiogenic effect of intercellular adhesion molecule-1.

Chengguo Deng¹, Duanlian Zhang, Shengguo Shan

¹Department of Histology & Embryology, Yunyang Medical College, Yunyang, China. dengdcg@sina.com

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban

|March 30, 2007

Summary

Intercellular adhesion molecule-1 (ICAM-1) promotes angiogenesis and supports microvessel survival, playing a role in embryonic blood vessel development. This study utilized the chick embryo chorioallantoic membrane (CAM) assay to investigate ICAM-1's angiogenic effects.

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Area of Science:

Vascular Biology
Developmental Biology
Immunology

Background:

Angiogenesis is crucial for development and disease.
Intercellular adhesion molecule-1 (ICAM-1) is implicated in various biological processes.
The specific role of ICAM-1 in angiogenesis requires further elucidation.

Purpose of the Study:

To investigate the angiogenic effects of ICAM-1 in vivo.
To determine if ICAM-1 promotes new blood vessel formation.
To assess ICAM-1's role in microvessel survival and embryonic angiogenesis.

Main Methods:

Chick embryo chorioallantoic membrane (CAM) assay for in vivo angiogenesis.
Administration of varying concentrations of ICAM-1 and anti-ICAM-1 antibodies.
Quantification of microvessel density and morphology.

Main Results:

ICAM-1 administration significantly increased microvessel formation with a "spoked-wheel" pattern.
Anti-ICAM-1 treatment inhibited microvessel growth and induced involution.
ICAM-1 demonstrated a dose-dependent effect on angiogenesis and microvessel survival.

Conclusions:

ICAM-1 possesses significant angiogenic properties.
ICAM-1 is involved in embryonic angiogenesis and microvessel maintenance.
Targeting ICAM-1 may offer therapeutic strategies for angiogenesis-related conditions.