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Updated: Jul 16, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
Synthesis of 1,3- and 1,2-diphosphatidylglycerol
Moghis U Ahmad1, U Murali Krishna, Shoukath M Ali
1NeoPharm, Inc., 1850 Lakeside Drive, Waukegan, IL 60085, USA.
Abstract:
A novel phosphonium salt methodology was utilized for the first time to synthesize 1,3-, and 1,2-diphosphatidylglycerol. Optically active 1,2-di-O-acyl-sn-glyceryl phosphate was coupled with unprotected glycerol in the presence of pyridiniumbromide perbromide and triethylamine to yield, after final removal of phosphate protecting group, the title compounds. The 1,2-diphosphatidylglycerol (1,2-isomer of cardiolipin) may be a member of a new class of phospholipids for industrial applications similar to other phosphocholines.
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