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Published on: January 17, 2012
The novel MGC13096 protein is correlated with proliferation
Qiu Chen1, Chengqi Yan, Qingfeng Yan
1College of Life Sciences, Zhejiang University, Hangzhou, PR China.
Abstract:
We report a functional characterisation of the novel protein MGC13096. MGC13096 over-expression restrained proliferation of HEK293T cells. DNA/flow cytometry analysis showed that the over-expression of MGC13096 severely delays cell cycle progression at S phase. Transcription factors such as activator protein-1 (AP-1), cAMP response element binding protein (CREB), nuclear factor of activated T cells (NFAT), NF-kappaB, signal transducer and activator of transcription 1 (STAT1) took part in the process.
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