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New bioactive natural products from Coprinus micaceus
Shamsulhaq Zahid1, Chibuike C Udenigwe, Athar Ata
1Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9.
Natural Product Research
|March 31, 2007
Summary
Researchers discovered two new natural products from the mushroom Coprinus micaceus: micaceol, a sterol with antibacterial properties, and a novel compound that inhibits glutathione S-transferase.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Mycology
Background:
- Coprinus micaceus is a mushroom species found in the Canadian Prairies.
- Fungal extracts are a rich source of novel bioactive compounds.
- Previous chemical investigations of this species were limited.
Purpose of the Study:
- To isolate and characterize new natural products from Coprinus micaceus.
- To evaluate the biological activities of the isolated compounds.
Main Methods:
- Methanolic extraction of Coprinus micaceus fruiting bodies.
- Isolation and purification of compounds using chromatographic techniques.
- Structure elucidation via extensive Nuclear Magnetic Resonance (NMR) spectroscopy.
Main Results:
- Two new compounds were isolated: micaceol (1), a sterol, and (Z,Z)-4-oxo-2,5-hetpadienedioic acid (2).
- Compound 2 represents the first isolation of this compound from a natural source.
- Micaceol (1) demonstrated antibacterial activity against Corynebacterium xerosis and Staphylococcus aureus.
- Compound 2 exhibited glutathione S-transferase inhibition.
Conclusions:
- Coprinus micaceus is a source of novel bioactive natural products.
- Micaceol and (Z,Z)-4-oxo-2,5-hetpadienedioic acid possess distinct biological activities.
- Further investigation into these compounds may lead to new therapeutic agents.
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