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Updated: Aug 24, 2026

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells
Published on: July 29, 2010
Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription
1Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104-6145.
Abstract:
Transcriptional control of the Ig heavy chain and kappa light chain is dominated by single enhancers located within the body of each gene. These enhancers bind distinct, yet overlapping, sets of cell-type-specific and ubiquitous nuclear proteins. This review focuses on one particular subclass of enhancer-binding protein, termed helix-loop-helix (HLH) proteins, describing their role in the establishment of cell-type-specific transcription and suggesting how they may be regulated during B-cell maturation.
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