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Intrathecal baclofen. Effects on nocturnal leg muscle spasticity
H M Kravitz1, D M Corcos, G Hansen
1Department of Psychiatry, Rush-Presbyterian-Saint Luke's Medical Center, College of Kinesiology, University of Illinois, Chicago 60680.
American Journal of Physical Medicine & Rehabilitation
|February 1, 1992
Abstract:
Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design. Tibialis anterior electromyographic activity per hour of sleep was reduced on the night of baclofen infusion. In particular, less electromyographic activity occurred after arousal from sleep.