Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Volume guarantee ventilation.

Martin Keszler1, Kabir M Abubakar

  • 1Division of Neonatal-Perinatal Medicine, Georgetown University Hospital, Washington DC 20007, USA. keszlerm@gunet.georgetown.edu

Clinics in Perinatology
|March 31, 2007
PubMed
Summary

New ventilators improve control of delivered tidal volume, crucial for preventing lung injury and brain damage in neonates. These advancements offer consistent tidal volumes, reducing risks associated with mechanical ventilation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlation of Oxygen Saturation Index with Oxygenation Index in Congenital Diaphragmatic Hernia: in A Secondary Analysis of a Randomized Clinical Trial.

The Journal of pediatrics·2026
Same author

Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants: The PDA Randomized Clinical Trial.

JAMA·2025
Same author

Increased Mean Airway Pressure Is Associated With Successful Transition to a Portable Home Ventilator in Patients With Grade 3 Bronchopulmonary Dysplasia.

Pediatric pulmonology·2025
Same author

Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: The Budesonide in Babies (BiB) Randomized Clinical Trial.

JAMA·2025
Same author

Alternative consent processes in a neonatal resuscitation trial (SAIL): secondary analysis of an open-label, international, multicentre, randomised trial.

The Lancet. Child & adolescent health·2025
Same author

The Lancet Child & Adolescent Health Commission on the future of neonatology.

The Lancet. Child & adolescent health·2025

Area of Science:

  • Neonatal critical care
  • Respiratory physiology
  • Mechanical ventilation

Background:

  • Ventilator-induced lung injury (VILI) is linked to volume, not just pressure.
  • Hypocarbia (low carbon dioxide) in neonates is associated with brain injury.
  • Current ventilators struggle to consistently deliver precise tidal volumes.

Purpose of the Study:

  • To review new microprocessor-based ventilator technologies.
  • To discuss automatic weaning of peak inspiratory pressure.
  • To highlight benefits of controlled tidal volume delivery.

Main Methods:

  • Review of microprocessor-based ventilator modalities.
  • Discussion of automatic weaning algorithms.
  • Analysis of short-term clinical trial data.

Main Results:

  • Consistent tidal volume delivery.
  • Reduction in excessively large breaths.
  • Lower peak inspiratory pressures and hypocapnia.
  • Shorter duration of mechanical ventilation.
  • Decreased levels of inflammatory cytokines.

Conclusions:

  • New ventilator technology offers improved tidal volume control.
  • Short-term benefits include reduced lung injury markers and ventilation duration.
  • Long-term impact on chronic lung disease requires further investigation.

Related Experiment Videos