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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Modified RIFLE criteria in critically ill children with acute kidney injury
A Akcan-Arikan1, M Zappitelli, L L Loftis
1Renal Section, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas 77030, USA.
Kidney International
|March 31, 2007
Summary
The pediatric RIFLE (pRIFLE) criteria identified acute kidney injury in most critically ill children early in intensive care. This condition independently predicted longer hospital stays and increased mortality risk.
Area of Science:
- Pediatric Nephrology
- Critical Care Medicine
- Renal Physiology
Background:
- Acute kidney injury (AKI) diagnosis in adults uses the Risk, Injury, Failure, Loss, and End-stage renal disease (RIFLE) criteria.
- Standardized AKI definitions are crucial for pediatric critical care research and patient management.
Purpose of the Study:
- To adapt and validate the RIFLE criteria for critically ill children, termed pediatric RIFLE (pRIFLE).
- To assess the incidence, course, and impact of AKI in critically ill pediatric patients using pRIFLE criteria.
Main Methods:
- Retrospective analysis of 150 critically ill pediatric patients.
- Application of modified RIFLE criteria (pRIFLE) to assess AKI severity and timing.
- Statistical analysis to determine AKI as a predictor of outcomes, adjusting for the Pediatric Risk of Mortality (PRISM II) score.
Main Results:
- 82% of AKI cases occurred within the first week of intensive care admission.
- AKI was an independent predictor of increased intensive care and hospital length of stay (OR 3.0).
- AKI independently predicted an increased risk of death, irrespective of the PRISM II score.
Conclusions:
- The pRIFLE criteria effectively characterize AKI patterns in critically ill children.
- Early identification and management of AKI in pediatric intensive care are critical.
- AKI is associated with significant morbidity, mortality, and increased healthcare costs in critically ill children.
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