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Impact of pharmacogenomics on clinical practice in oncology

Sharon Marsh1

  • 1Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA. smarsh@im.wustl.edu

Molecular Diagnosis & Therapy
|April 3, 2007
PubMed

Insights

Pharmacogenomics is advancing cancer treatment by guiding drug selection. Genetic testing for TPMT and UGT1A1 variants, alongside genotype-guided trials, improves personalized oncology therapy decisions.

Area of Science:

  • Pharmacogenomics
  • Oncology
  • Clinical Pharmacology

Background:

  • Multiple drug strategies are available for cancer treatment, necessitating tools for informed therapy selection.
  • Individualized cancer treatment selection via pharmacogenomics is a long-term goal with significant ongoing progress.

Purpose of the Study:

  • To highlight advances in cancer pharmacogenomics and their incorporation into clinical practice.
  • To discuss the role of genetic testing in optimizing cancer drug therapy selection and patient outcomes.

Main Methods:

  • Review of current pharmacogenomic applications in oncology.
  • Examples include genetic testing for thiopurine methyltransferase (TPMT) and UGT1A1*28 variant alleles.
  • Mention of genotype-guided clinical trials, such as those involving TYMS.

Main Results:

  • Genetic testing for TPMT variants before mercaptopurine and UGT1A1*28 before irinotecan are key advances.
  • Genotype-guided clinical trials demonstrate progress in applying pharmacogenomics.
  • Despite unknown markers for many drugs, progress is evident in integrating pharmacogenomics into oncology.

Conclusions:

  • Pharmacogenomics shows significant promise for individualized cancer treatment selection.
  • Current advances in genetic testing and clinical trials are paving the way for routine pharmacogenomic application in oncology.
  • Further research is needed to identify more genetic markers for drug toxicity and efficacy.

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