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Related Experiment Video

Updated: Feb 10, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

24.0K

Taxane pharmacogenetics.

Sharon Marsh1

  • 1Washington University School of Medicine, Division of Oncology, 660 South Euclid Ave - Campus Box 8069, St Louis, MO 63110, USA. smarsh@im.wustl.edu.

Personalized Medicine
|May 23, 2018
PubMed
Summary
This summary is machine-generated.

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Taxanes like paclitaxel and docetaxel show variable patient responses and toxicity. Epigenetic factors may explain these differences, guiding personalized cancer therapy.

Area of Science:

  • Oncology
  • Pharmacogenomics

Background:

  • Taxanes (paclitaxel, docetaxel) are chemotherapy drugs that stabilize microtubules, inhibiting cancer cell division.
  • Significant interindividual variability exists in patient response and toxicity to these taxanes.
  • Genetic variations in taxane metabolism and transport genes are known, but useful predictive markers are limited.

Purpose of the Study:

  • To explore the role of epigenetic regulation in explaining the variability of taxane response and toxicity.
  • To identify potential epigenetic markers for individualized taxane therapy.

Main Methods:

  • Review of existing literature on taxane pharmacokinetics, pharmacodynamics, and pharmacogenetics.
  • Analysis of studies investigating epigenetic modifications (e.g., DNA methylation, histone modification) in taxane pathway genes.
Keywords:
cancerdocetaxelepigeneticmicrotubulepaclitaxelpharmacogeneticspolymorphismtaxane

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Last Updated: Feb 10, 2026

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  • Correlation of epigenetic alterations with observed patient response and toxicity data.

    • Main Results:

    • Genetic variability alone does not fully account for interpatient differences in taxane efficacy and side effects.
    • Emerging evidence suggests epigenetic mechanisms significantly influence the expression and function of genes involved in taxane action.
    • Specific epigenetic patterns may be associated with heightened taxane toxicity or reduced treatment response.

    Conclusions:

    • Epigenetic regulation of taxane pathway genes is a critical factor contributing to variable patient outcomes.
    • Targeting epigenetic modifications could offer novel strategies for personalizing taxane chemotherapy.
    • Further research into epigenetic markers is warranted for improved patient selection and treatment optimization.