Novel chalcogenides of thymidine and uridine: synthesis, properties and applications
Kirubakaran Sivapriya1, Perumal Suguna, S Shubashree
1Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.
Abstract:
A facile and efficient methodology has been developed for the synthesis of dithymidine and di-uridine derived disulfides using benzyltriethylammonium tetrathiomolybdate as a sulfur transfer reagent. However, a similar reaction of thymidine derivative with tetraethylammonium tetraselenotungstate as a selenium transfer reagent resulted in the formation of an unexpected cyclic diselenide. The disulfide derivatives of nucleosides have been used as precursors in a tandem disulfide cleavage-Michael addition/ring opening reactions to construct aminoacid and carbocyclic derivatives of nucleosides.
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