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Updated: Sep 6, 2025

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Published on: September 6, 2019
Synthesis of Hexenuloses and a Library of Disaccharides Possessing 3-oxo-glycal Unit
Perali Ramu Sridhar1, Intzar Ali1, M V Kamala Lakshmi1
1School of Chemistry, University of Hyderabad, C. R. Rao Road, Gachibowli, Hyderabad 500 046, India.
Abstract:
An expeditious method for the synthesis of monosaccharides and disaccharides possessing 3-oxo-glycal units is revealed. Several monosaccharides and disaccharide-derived glycals are converted to the corresponding hexenuloses in three steps involving halo-alkoxylation, dehydrohalogenation, and ketalyzation reactions. A number of 3-oxo-glycals are synthesized to show the methodology's importance and generality. Further, the protocol is successfully applied to synthesize a rare-sugar disaccharide donor unit present as part of the trisaccharide moiety in the reported natural product, versipelostatin.
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