Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between Neisseria meningitidis and the complement system.

Muriel C Schneider1, Rachel M Exley, Sanjay Ram

  • 1Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK.

Trends in Microbiology
|April 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C4BP occludes the non-opsonic interaction of <i>Neisseria gonorrhoeae</i> with human neutrophil CEACAMs.

Infection and immunity·2026
Same author

Pre-clinical efficacy of a candidate outer membrane vesicle gonococcal vaccine in comparison with 4CMenB.

NPJ vaccines·2026
Same author

Correction: Origin, evolution, and success of pbla, the gonococcal beta-lactamase plasmid, and implications for public health.

PLoS pathogens·2026
Same author

Perspective on the pathogenic Neisseria: milestones, challenges, and future directions.

NPJ vaccines·2026
Same author

Plasmids in <i>Neisseria gonorrhoeae</i>: drivers of DoxyPEP failure and an emerging threat for current therapy.

Clinical microbiology reviews·2026
Same author

Gonococcal outer membrane vesicle vaccines: bacterial population biology, clinical trials, immune profiling, and vaccine design.

NPJ vaccines·2026
Same journal

Host membranes provide hidden gateways for 'accidental pathogens'.

Trends in microbiology·2026
Same journal

Structural inequalities in global antimicrobial resistance governance.

Trends in microbiology·2026
Same journal

Environmental microbes as modulators of plant volatile landscapes: Implications for plant-insect chemical communication.

Trends in microbiology·2026
Same journal

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools.

Trends in microbiology·2026
Same journal

Cronobacter spp.

Trends in microbiology·2026
Same journal

Anaerobic lignin deconstruction: A game changer for lignocellulosic biorefineries.

Trends in microbiology·2026
See all related articles

Neisseria meningitidis evades the human complement system using bacterial structures to prevent immune attack. Understanding these evasion mechanisms and human genetic variations is key to combating meningococcal infections.

Area of Science:

  • Immunology
  • Microbiology
  • Genetics

Background:

  • Meningococcal infection is a significant global health concern.
  • The complement system is essential for defense against Neisseria meningitidis.
  • N. meningitidis employs sophisticated strategies to evade complement-mediated immunity.

Purpose of the Study:

  • To review recent findings on Neisseria meningitidis evasion mechanisms.
  • To explore how host complement gene polymorphisms influence susceptibility.

Main Methods:

  • Literature review of current research on N. meningitidis immune evasion.
  • Analysis of bacterial factors (capsule, host molecule mimicry) involved in complement resistance.
  • Examination of human complement gene polymorphisms and their impact on disease risk.

Related Experiment Videos

Main Results:

  • N. meningitidis utilizes its polysaccharide capsule and host-mimicking molecules to resist complement.
  • These bacterial structures inhibit complement-mediated lysis and phagocytosis.
  • Variations in human complement genes correlate with differing susceptibility to meningococcal disease.

Conclusions:

  • Neisseria meningitidis has evolved diverse mechanisms to counteract the complement system.
  • Host genetic factors, specifically complement protein polymorphisms, play a critical role in determining susceptibility to meningococcal infections.
  • Further research into these interactions is vital for developing effective prevention and treatment strategies.