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Published on: June 22, 2017
Understanding triclabendazole resistance.
G P Brennan1, I Fairweather, A Trudgett
1Queen's University of Belfast, Belfast, N. Ireland. g.brennan@qub.ac.uk
Experimental and Molecular Pathology
|April 3, 2007
Summary
Triclabendazole resistance in liver flukes is a growing concern for livestock and human health. Understanding resistance mechanisms is crucial for developing new strategies against fascioliasis.
Area of Science:
- Veterinary Parasitology
- Drug Resistance Mechanisms
- Molecular Biology
Background:
- Triclabendazole (TCBZ) is the primary anthelmintic for liver fluke infections in livestock and humans.
- Over two decades of use have led to widespread TCBZ resistance in liver fluke populations globally.
- The reliance on TCBZ for fascioliasis treatment is threatened by emerging resistance.
Purpose of the Study:
- To review the current understanding of TCBZ resistance mechanisms in liver flukes.
- To explore potential strategies for managing and overcoming TCBZ resistance.
- To highlight the urgent need for alternative treatment options.
Main Methods:
- Literature review of studies on TCBZ resistance in Fasciola species.
- Analysis of proposed mechanisms including target site modification, drug transport, and metabolism.
- Examination of current and future therapeutic approaches.
Main Results:
- TCBZ resistance has been reported in Australia, Europe (Ireland, Scotland, Wales, Spain, Netherlands).
- Mechanisms of resistance may involve alterations in the fluke's target molecule, drug influx/efflux, or TCBZ metabolism.
- The development of resistance poses a significant risk to effective fascioliasis control.
Conclusions:
- Urgent need to understand TCBZ resistance mechanisms to inform treatment strategies.
- Alternative drugs, combination therapies, and novel compound discovery are essential.
- Proactive management is required to mitigate the impact of TCBZ resistance on animal and human health.
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