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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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[Needle breakage: a rare and potentially dangerous complication during local anaesthesia]

I Dojcinovic1, M Hugentobler, M Richter

  • 1Service de chirurgie maxillofaciale et de chirurgie buccale, département de chirurgie, hôpital cantonal de Genève, 24, rue Micheli-du-Crest, 1211 Genève, Suisse. ivan.dojcinovic@hcuge.ch

Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|April 3, 2007
PubMed
Abstract

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Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...