Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The future of endoscopic sinus surgery in chronic rhinosinusitis.

Rhinology·2026

Same author

Magnetic resonance imaging in gustatory disorders: diagnostic usefulness with a cost analysis.

Rhinology·2025

Same author

Development and psychometric validation of the Chronic Rhinosinusitis Control Test.

Rhinology·2025

Same author

Inflammatory predictors of Post-COVID fatigue.

Brain, behavior, & immunity - health·2025

Same author

Intranasal trigeminal and secretory functions are impaired after topical anaesthesia or surgical treatment of epistaxis.

Rhinology·2025

Same author

Olfactory implants: international opinion paper on emerging technologies and clinical applications.

Rhinology·2025

Same journal

Real world efficacy of dupilumab in switchers versus biological naive CRSwNP patients.

Rhinology·2026

Same journal

Therapeutic outcomes of biologic switching in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.

Rhinology·2026

Same journal

Association between chronic obstructive pulmonary disease and chronic rhinosinusitis: a longitudinal follow-up study using a national health insurance database.

Rhinology·2026

Same journal

Metropolitan air pollution and the upper and lower airway: chronic rhinosinusitis and asthma outpatient burden.

Rhinology·2026

Same journal

Impact of real-world confounders on the accuracy of an AI model to support read out of skin prick automated test results.

Rhinology·2026

Same journal

Factors influencing timing of cerebrospinal fluid leak after endoscopic skull base surgery: a multicenter study.

Rhinology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 11, 2025

A Free-breathing fMRI Method to Study Human Olfactory Function

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

Can MRI predict olfactory loss and improvement in posttraumatic olfactory dysfunction?

J W Hsieh¹, V Lenoir², R Sipione³

¹Rhinology-Olfactory Unit, Department of Otorhinolaryngology - Head and Neck Surgery, Geneva University Hospitals, Geneva, Switzerland; The Inner Ear and Olfaction Lab, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

|November 13, 2023

Summary

This summary is machine-generated.

Brain MRI patterns can classify post-traumatic olfactory dysfunction (PTOD) severity and predict olfactory improvement. Milder brain lesions correlate with better smell recovery in PTOD patients.

More Related Videos

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Published on: January 19, 2024

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

Related Experiment Videos

Last Updated: Jul 11, 2025

A Free-breathing fMRI Method to Study Human Olfactory Function

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Published on: January 19, 2024

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

Area of Science:

Neuroimaging
Olfactory dysfunction
Traumatic brain injury

Background:

Post-traumatic olfactory dysfunction (PTOD) is common after head injury.
The diagnostic and prognostic value of MRI in PTOD remains unclear.
Current understanding lacks classification of neurodegeneration extent and MRI's predictive capability for olfactory recovery.

Purpose of the Study:

To classify the extent of neurodegeneration in patients with PTOD using MRI.
To correlate MRI findings with chemosensory dysfunction (smell, taste, trigeminal).
To determine if MRI can predict olfactory improvement in PTOD.

Main Methods:

Retrospective cohort study of 56 PTOD patients.
Patients underwent psychophysical tests for smell, taste, and trigeminal functions, and MRI.
Radiologist evaluated 40 brain regions for lesions; follow-up data available for 46 patients.

Main Results:

Four distinct brain lesion patterns identified, associated with anosmia, hyposmia, and normosmia.
Two clusters showed 100% specificity and positive predictive value for anosmia.
Mild lesions predicted a 72.7% chance of olfactory improvement, significantly higher than larger lesions (21.7-37.5%).

Conclusions:

Brain lesion analysis via MRI aids in corroborating smell test results in PTOD.
MRI findings can predict both subjective and measurable olfactory improvement.
This study establishes MRI's prognostic value in managing post-traumatic smell loss.