Related Experiment Video
Updated: Jul 15, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
Published on: March 1, 2024
A temporal hidden Markov regression model for the analysis of gene regulatory networks
Mayetri Gupta1, Pingping Qu, Joseph G Ibrahim
1Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. gupta@bios.unc.edu
Abstract:
We propose a novel hierarchical hidden Markov regression model for determining gene regulatory networks from genomic sequence and temporally collected gene expression microarray data. The statistical challenge is to simultaneously determine the groupings of genes and subsets of motifs involved in their regulation, when the groupings may vary over time, and a large number of potential regulators are available. We devise a hybrid Monte Carlo methodology to estimate parameters under 2 classes of latent structure, one arising due to the unobservable state identity of genes and the other due to the unknown set of covariates influencing the response within a state. The effectiveness of this method is demonstrated through a simulation study and an application on an yeast cell-cycle data set.
More Related Videos
10:44Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
Published on: December 7, 2021
11:36An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
Published on: April 21, 2023
Related Concept Videos
Regulation of Expression at Multiple Steps
Master Transcription Regulators
Constitutive and Regulated Gene Expression
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Cis-regulatory Sequences