Effect of war on the menstrual cycle
Antoine B Hannoun1, Anwar H Nassar, Ihab M Usta
1American University of Beirut Medical Center, Beirut, Lebanon. ahannoun@aub.edu.lb
Obstetrics and Gynecology
|April 3, 2007
Summary
A short war period caused menstrual irregularities in 10-35% of women, likely due to stress. Most women
Area of Science:
- Reproductive Health
- Psychosomatic Medicine
- Sociomedical Sciences
Background:
- War and conflict situations represent significant stressors.
- The impact of acute stress on women's reproductive health, specifically menstrual cycles, requires further investigation.
Purpose of the Study:
- To investigate the effects of a brief war period on the menstrual cycles of women exposed to conflict.
- To assess the duration and reversibility of war-induced menstrual abnormalities.
Main Methods:
- A cohort study involving women aged 15-45 years in war-exposed villages and a control group.
- Menstrual history data were collected via questionnaires at baseline, 3 months, and 6 months post-war.
- Analysis compared menstrual aberrations in women with varying exposure durations (Group A: 3-16 days in war zone; Group B: displaced within 2 days; Group C: control).
Main Results:
- Menstrual aberrations were observed in over 35% of Group A and 10.5% of Group B women 3 months post-war, significantly higher than the control group (2.6%).
- Six months after the war, most women experienced cycle normalization, though 18.6% in Group A still had irregularities.
- The incidence of menstrual abnormalities correlated with the duration of exposure to the war zone.
Conclusions:
- Acute stress from a short war period can induce menstrual abnormalities in a significant percentage of women.
- These war-related menstrual irregularities may persist for more than two cycles.
- Most menstrual cycle disturbances resolved spontaneously without medical intervention.
Related Concept Videos
The Menstrual Cycle
The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
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The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a uterine...
Hormonal Regulation of the Menstrual Cycle
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Menses Phase
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
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Disorders of the Female Reproductive System
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Secretory Phase
The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
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The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...

