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Updated: Jul 15, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Autonomic status in systemic sclerosis in India.
Raj Kumar Yadav1, Rajiva Gupta, Molly Mary Thabah
1Department of Physiology, All India Institute of Medical Sciences, New Delhi.
Indian Journal of Physiology and Pharmacology
|April 4, 2007
Summary
Systemic sclerosis patients exhibit higher heart rate and respiratory rate, indicating autonomic dysfunction. Specifically, they show reduced parasympathetic tone and reactivity, impacting cardiovascular control.
Area of Science:
- Cardiology
- Rheumatology
- Neurology
Background:
- Systemic sclerosis (SSc) is a connective tissue disease linked to vasomotor disturbances.
- Autonomic dysfunction is increasingly recognized in SSc pathogenesis.
- Understanding autonomic function is crucial for managing SSc symptoms.
Purpose of the Study:
- To investigate autonomic function in Indian patients with Systemic Sclerosis.
- To compare autonomic parameters between SSc patients and healthy controls.
- To elucidate the role of autonomic dysfunction in SSc.
Main Methods:
- Retrospective study design.
- Inclusion of 30 SSc patients and 30 age-matched healthy controls.
- Standardized autonomic function tests including tone and reactivity assessments.
Main Results:
- SSc patients demonstrated significantly higher heart rate (HR) and respiratory rate (RR) compared to controls (P=0.0001 and P=0.012, respectively).
- Significantly lower parasympathetic tone and parasympathetic reactivity were observed in SSc patients.
- Findings suggest a reduced central parasympathetic drive to the heart in SSc.
Conclusions:
- Autonomic dysfunction, particularly impaired parasympathetic activity, is prevalent in Indian SSc patients.
- These findings contribute to understanding the multisystemic nature of SSc.
- Further research may offer insights into the etiology and management of SSc.
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