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[Alkaloids from annonaceae.].

A Jossang1, M Lebœuf, P Cabalion

  • 1Laboratoire de Pharmacognosie, E.R.A. 317 C.N.R.S., Faculté de Pharmacie, Châtenay-Malabry, France.

Planta Medica
|September 1, 1983
PubMed
Summary
This summary is machine-generated.

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Thirteen isoquinoline alkaloids were identified from POLYALTHIA NITIDISSIMA, including four novel bisbenzylisoquinoline dimers. This research expands the known chemical diversity of this plant genus.

Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Organic Chemistry

Context:

  • The plant POLYALTHIA NITIDISSIMA is a source of diverse chemical compounds.
  • Isoquinoline alkaloids represent a significant class of natural products with various biological activities.
  • Previous research may not have fully explored the alkaloid profile of POLYALTHIA NITIDISSIMA.

Purpose:

  • To isolate and identify chemical constituents from POLYALTHIA NITIDISSIMA.
  • To characterize the structural diversity of alkaloids present in the plant.
  • To discover and report new natural products.

Summary:

  • Thirteen isoquinoline alkaloids were successfully isolated and identified from different parts of POLYALTHIA NITIDISSIMA.
  • The identified alkaloids encompass structural types including benzylisoquinolines, aporphinoids, protoberberines, and predominantly bisbenzylisoquinolines.

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  • Four of the isolated bisbenzylisoquinoline dimers, N,N'-dimethyllindoldhamine, isodaurisoline, 7-O-methyllindoldhamine, and 7'-O-methyllindoldhamine, are reported as new natural products.

    • Impact:

    • This study contributes to the understanding of the phytochemical profile of POLYALTHIA NITIDISSIMA.
    • The discovery of new alkaloids expands the library of known natural products for further pharmacological investigation.
    • The findings provide a basis for potential future research into the biological activities and applications of these isoquinoline alkaloids.