[Studies for analyzing the prohibited ingredients such as selenium disulfide in cosmetics]

Area of Science:

• Analytical Chemistry
• Cosmetic Science
• Environmental Health

Background:

• Selenium disulfide is banned in Japanese cosmetics under the Pharmaceutical Affairs Act.
• Accurate detection methods are crucial for enforcing cosmetic ingredient regulations.

Purpose of the Study:

• To establish a reliable analytical method for quantifying selenium disulfide in cosmetic products.
• To ensure compliance with Japanese regulations on prohibited cosmetic ingredients.

Main Methods:

• Developed an Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method.
• Utilized microwave-assisted acid digestion for sample preparation.
• Validated the method with a linear working curve (10–1000 µg/L) and a detection limit of 22 µg/L.

Main Results:

• The ICP-MS method successfully quantified selenium disulfide in a shampoo matrix.
• No interference was observed from other shampoo ingredients.
• Achieved a low detection limit, suitable for regulatory compliance.

Conclusions:

• The developed ICP-MS method is effective for determining selenium disulfide in cosmetics.
• This method supports regulatory enforcement and ensures consumer safety regarding prohibited ingredients.