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A thyroxine-containing peptide can induce murine experimental autoimmune thyroiditis.

P R Hutchings¹, A Cooke, K Dawe

¹Immunology Department, University College and Middlesex Medical School, London, United Kingdom.

The Journal of Experimental Medicine

|March 1, 1992

Summary

A specific peptide from thyroglobulin (Tg) containing thyroxine (T4) triggers autoimmune thyroiditis in mice. This T4-containing sequence is identified as a major thyroiditogenic epitope, crucial for disease development.

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Area of Science:

Immunology
Endocrinology
Molecular Biology

Background:

Thyroglobulin (Tg) is a key autoantigen in autoimmune thyroid diseases.
Autoreactive T cells play a critical role in the pathogenesis of thyroiditis.

Purpose of the Study:

To identify and characterize a specific thyroiditogenic epitope within thyroglobulin.
To investigate the role of thyroxine (T4) in the induction of autoimmune thyroiditis.

Main Methods:

A synthetic peptide based on a Tg sequence containing T4 was used.
Primed lymph node cells from immunized mice were transferred to naive recipients.
In vitro antigen re-exposure and induction of thyroiditis were assessed.

Main Results:

Related Experiment Videos

A T4-containing 12mer peptide from Tg triggered thyroiditis in mice.
Both intact Tg and the peptide could prime lymph node cells for disease induction.
Depletion of T4 from Tg peptides abolished their ability to stimulate pathogenic T cells.

Conclusions:

The T4-containing 12mer sequence represents a major thyroiditogenic epitope in CBA/J mice.
The thyroxine residue is critical for the induction of autoimmune thyroiditis by this epitope.
Other pathogenic epitopes may exist within the thyroglobulin molecule.