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Measurement of Elecsys NT-proBNP in serum, K2 EDTA and heparin plasma
Giuseppe Lippi1, Gian Luca Salvagno, Martina Montagnana
1Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Ospedale Policlinico G.B. Rossi, Piazzale Scuro, 10, 37134-Verona, Italy. giuseppe.lippi@univr.it
Objective:
There is controversial evidence on a matrix influence on the measurement of NT-proBNP.
Design And Methods:
We compared results of Elecsys NT-proBNP measurement on serum, K2 EDTA plasma and lithium heparin plasma.
Results:
Samples collected in K2 EDTA showed a marginally significant underestimation when compared to serum and heparin, whereas no significant difference was observed between serum and heparin plasma.
Conclusions:
Serum, heparin and K2 EDTA plasma may be suitable for NT-proBNP measurement.
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