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Updated: Jul 15, 2026
04:10
Robotic-assisted Bronchoscopy Combined with Multimodal Imaging for Targeted Lung Cryobiopsies
Published on: July 19, 2024
Improved diagnostic efficacy by rapid cytology test in fluoroscopy-guided bronchoscopy
Junji Uchida1, Fumio Imamura, Akemi Takenaka
1Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka, Japan. utida-ju@mc.pref.osaka.jp
Summary
Rapid on-site cytopathologic examinations (ROSE) significantly improved the diagnostic yield of fluoroscopy-guided bronchoscopy for peripheral lung nodules. Routine use of ROSE is recommended to enhance diagnostic accuracy for pulmonary malignancies.
Area of Science:
- Pulmonology
- Oncology
- Diagnostic Imaging
Background:
- Fluoroscopy-guided bronchoscopy is standard for lung nodule biopsy but has low sensitivity for malignancy.
- The diagnostic value of rapid on-site cytopathologic examinations (ROSE) during bronchoscopy remains unclear.
Purpose of the Study:
- To evaluate the impact of ROSE on the diagnostic yield of fluoroscopy-guided bronchoscopy for peripheral lung lesions.
Main Methods:
- A prospective study of 657 patients with suspected malignant lung lesions undergoing fluoroscopy-guided bronchoscopy.
- Rapid on-site cytopathologic examinations (ROSE) were performed, with additional procedures if ROSE was not diagnostic.
Main Results:
- ROSE increased the overall diagnostic yield of bronchoscopy from 74.4% to 90.3%.
- For lesions <=2 cm, ROSE improved diagnosis of malignant peripheral lesions by an additional 23.0%.
- ROSE enhanced diagnostic accuracy regardless of lesion characteristics or operator experience.
Conclusions:
- ROSE is an effective reinforcement for bronchoscopic diagnosis of peripheral pulmonary malignancies.
- Routine implementation of ROSE in bronchoscopy should be encouraged to improve diagnostic rates.
