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Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Circadian Rhythms and Gene Regulation

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Cancer Therapies

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Related Experiment Video

Updated: Jul 15, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

[Dynamic circadian system patients under chimiotherapy].

J Beau¹, I Iurisci, T Beau

¹Rythmes biologiques et cancers, Inserm U 776, hôpital Paul-Brousse, 12, avenue P.-Vaillant-Couturier, 94800 Villejuif, France. beau@vjf.inserm.fr

Pathologie-Biologie

|April 7, 2007

Summary

This study introduces a new method to analyze patient activity data, revealing how chemotherapy impacts the body's internal clock. The findings detail chemotherapy's effects on the circadian timing system and its recovery pattern.

Related Experiment Videos

Last Updated: Jul 15, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Area of Science:

Chronobiology
Cancer Research
Signal Processing

Context:

The circadian timing system regulates physiological processes and is often disrupted in cancer patients.
Wrist actimetry is a common tool for collecting continuous activity data in patients.
Chemotherapy can significantly alter the body's biological rhythms.

Purpose:

To develop and apply a novel method for analyzing circadian rhythm alterations in cancer patients undergoing chemotherapy.
To assess the stability of the circadian timing system before chemotherapy.
To quantify chemotherapy-induced modifications in activity amplitude and rhythm structure.
To investigate the recovery patterns of the circadian system post-chemotherapy.

Summary:

A wavelet transform was used to establish a circadian model function before chemotherapy.
The correlation between this model and the patient's activity rhythm throughout treatment and recovery was measured.
This analysis highlights specific characteristics of chemotherapy-induced circadian system alterations and their recovery.

Impact:

Provides a quantitative method to understand chemotherapy's impact on circadian rhythms.
Offers insights into the recovery dynamics of the circadian timing system.
Potential to inform supportive care strategies for cancer patients undergoing chemotherapy.